Conversations with the Masters of Healing – FREE Teleseminar Intensive
I’m thrilled to announce the kick off of the inaugural teleseminar intensive – Conversations with the Masters of Healing – starting next month!
Conversations with the Masters of Healing is a rare opportunity for you to listen, learn, change your life, and speak to the most incredible practitioners of healthcare and healing. To register click here.
This complimentary Program will run from July 13 to August 3rd, 2010 and includes an absolutely INCREDIBLE line-up of the top names in prevention and wellness . . .
HDL Cholesterol – Are you concerned about levels being too high?
Lisa Nelson: Are you concerned by unusually high HDL levels, such as greater than 100 mg/dl?
Dr. Shelby-Lane: The main function of HDL is to help soak up excess cholesterol from the walls of blood vessels and carry it to the liver, where it breaks down and is removed from the body in the bile.
Measuring for particle size and particle number is the best way to tell if HDL cholesterol levels are safe/healthy. This involves testing and it is usually measured under the guidelines of an “expanded lipid profile.” The usual and optimal range for HDL is (40 for men and 50 for women).
Expanded lipid profiles are necessary to look at particle size.
There are several laboratories (see below) with different lab techniques, who specialize in performing these tests and measurements.
* Liposcience (NMR in North Carolina)
* Spectracell Labs Lipoprotein Particle Profile (LPP) (Houston, Texas…..my preferred lab)
* Berkeley Heart Lab with apoA phenotype (more expensive) in California
* Quest Labs with the VAP test (nationwide)
The laboratory test for HDL actually measures how much cholesterol is in the HDL, not the actual amount of HDL in the blood.
Normal Results and General Guidelines:
In general, your risk for heart disease, including a heart attack, increases if your HDL cholesterol level is less than 40 mg/dL.
Men are at particular risk if their HDL is below 37 mg/dL.
Women are at particular risk if their HDL is below 47 mg/dL.
An HDL 60 mg/dL or above helps protect against heart disease.
Women tend to have higher HDL cholesterol than men.
Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What Abnormal Results Mean
Low HDL levels may indicate an increased risk of atherosclerotic heart disease.
Abnormally high tests may be associated with:
Familial combined hyperlipidemia
Noninsulin-dependent diabetes (NIDDM)
According to (Natural News) The new scientific toolbox is being used to poke around in HDL’s “house”, only to find good news and bad news. HDL has been labeled “good” cholesterol because it helps remove damaged LDL cholesterol from your arteries and has generally been associated with having less cardiovascular disease. It is now coming to light that the quality of the HDL you have is as important, if not more important, than the amount of HDL you have. This means there is both “good HDL” and “bad HDL” and if you have too much of the bad HDL then it no longer protects you and actually helps cause heart disease. How do you know if you have good or bad HDL? You’d get an “expanded lipid profile” to learn the particle size and number of your HDL cholesterol molecules.
HDL is small in comparison to LDL, and it is higher in protein. It functions as a tow truck, latching on to spent or damaged LDL and returning it to your liver for recycling and/or clearance. The two main proteins that make up HDL are called apoA-I (75%) and apoA-II (25%). ApoA-I is the good guy, and its integrity of structure is vital for HDL’s ability to clear damaged LDL from your circulation and the walls of your arteries.
New discoveries are showing that apoA-I is also vital for HDL’s enzyme functions that give it anti-inflammatory and antioxidant activity. The role of apoA-II is much less understood, other than to say it is implicated as part of problems with fat metabolism and too much of it causes poor HDL function.
One aspect of HDL fitness is that as it does its work its supply of apoA-I is temporarily diminished and replaced by apoA-II. If HDL then fails to replenish apoA-I it loses its ability to function in a helpful cardiovascular way and actually becomes a problem to cardiovascular health. One key sign that a person lacks apoA-I and has too much apoA-II is elevating triglycerides.
Other research has more accurately defined the nature of the fatty substances that make up the HDL cell membrane. These are rich in phospholipids (phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and phosphatidylinositol). These phospholipids are linked to a unique cell membrane fat called sphingomyelin, which is used to make a major signaling molecule (Sphingosine-1-phosphate).
Triglycerides should never be more than twice your HDL, a relationship that in my opinion is far more important than your LDL/HDL ratio. The new science helps clarify why this is the case, explaining that as triglycerides go up then HDL quality goes down. In this handicapped condition HDL loses its ability to remove LDL, quench inflammation, and perform antioxidant functions.
What really has the science world buzzing is a newly recognized function of HDL as a major signaling molecule in your circulation, one that is acting as a communication platform to help instruct other cells around it what to do. Researchers have proven direct communication from HDL to the endothelial cells that line your arteries, the smooth muscle that comprises your arterial walls, the macrophages that are involved with LDL-related plaque formation, and T cells of your immune system.
Now for the bad news on Cholesterol
HDL can become damaged or “spent” at which point it no longer does any of these good things and instead actually contributes to cardiovascular disease, even winding up with LDL in plaque. There are three main reasons this happens.
1) The failure to provide adequate nutrition to re-energize HDL after it has been out working. This leads to a lack of apoA-I and an HDL cell membrane that has lost functionality.
2) Oxidative damage to apoA-I, caused by inflamed and overheated immune cells. This means individuals with inflammatory health issues will have poor quality HDL. The greater the inflammation, the worse the HDL quality.
3) Sugar glycation of HDL, rendering it “cemented” so that it can’t work. The more uncontrolled the blood sugar, the worse the HDL problem.
Lab tests that help to evaluate your heart are C-reactive protein, homocysteine, lipoprotein/(Lp(a), fibrinogen, ferritin, Total cholesterol (elevated), LDL cholesterol (elevated small –dense ldl particles), HDL cholesterol (reduced), Triglycerides (elevated), LDL and HDL particle size (pattern A and B) –VLDL, LDL particle number (increased number of particles), Apolipoproteins A and B, TG/HDL ratio of > 3.5 simple sign of insulin resistance.
Even if normal, you may still have significant heart disease. Kidney disease must also be ruled out as a cause. The gold standard for the diagnosis of coronary artery disease is a cardiac catheterization, but this is a fairly invasive test, and is not usually done without a history of severe and/or persistent symptoms or an actual heart attack. Other tests may include studies such as an ultrafast CT scan of the heart (if available, lots of radiation and soon to be taken off the market), a CT Angiogram, a nuclear stress test, an echocardiogram, a lipid profile for very low density lipids (with a complete cholesterol panel to look at subparticles), homocysteine level, HS-C-reactive protein, and an ankle-brachial index, just to name a few.
****** Discussing symptoms with your doctor is very important. ******
Please see your doctor for a detailed evaluation and examination, if you have concerns. Tests are ordered by your doctor, only if indicated, and after thorough review and evaluation.
Lisa Nelson RD: Let’s make sure everyone understood what you’ve said. HDL is protective and generally the more the better; however, new research is showing that there is “good” HDL and “bad” HDL. The only way to know the type you have is by completely an “expanded lipid profile” lab test. Correct?
Dr. Shelby-Lane: No, HDL is generally thought to be protective and the levels for routine testing of HDL is as follows: greater than 50 for women and greater than 40 for men. The range for norms depends upon the lab reference ranges which can go from 40 to 90. More specific testing uses the measurements for particle size/number and particle density. Therefore, once you look at particle size for HDL cholesterol, you can determine if you are dealing with an abnormal HDL molecule (particle size, density, and particle numbers) as well. The only way to know the type you have is by completing an “expanded lipid profile” lab test which must be ordered by your doctor. Additional testing is also performed in the expanded lipid profile such as Lp (a), HS – C-reactive protein, homocysteine, VLDL, ferritin, etc.
To learn more about Dr. Cynthia Shelby-Lane, you can check out the services she offers at www.elanantiaging.meta-ehealth.com.
Please share your comments below!
All the best,
Lisa Nelson RD
Heart Healthy Tips
http://www.hearthealthmadeeasy.com
Heart Disease – Link between Temperament, Personality, and Heart Disease Risk
Lisa Nelson RD: What role does temperament/personality play in a person’s heart disease risk?
Dr. Shelby-Lane: Temperament and personality have a definite effect on blood pressure and on heart disease. This is a great question and it has been studied by the experts, as you will note in the following excerpts. Heart disease consists of congenital abnormalities, arrhythmias, lipid abnormalities acquired and congenital, functional and physiologic problems, risk factors such as diabetes and metabolic syndrome, structural disease and valvular problems, heart failure, acquired disease such as coronary artery disuse, and infectious diseases along with diseases related to blood vessel structure. Again, anxiety, stress, and stress related disorders can have an effect on major hormones, heart rate and heart health and heart disease. Nutritional abnormalities can also affect heart performance.
New research suggests that people who suffer from panic attacks are at increased risk of developing heart disease.
Why people who suffer from panic attacks should be at increased risk of developing heart disease is unclear. According to the study, authors put forward several theories, one being that panic disorders might trigger nervous system changes which could promote the clogging of arteries. Another theory is that people may have been misdiagnosed as having panic attacks when they actually have coronary heart disease. “Clinicians should be vigilant for this possibility when diagnosing and treating people presenting with symptoms of panic,” said Dr Walters.
Study results have shown that people with depression are at increased risk of heart attack and heart failure because they are less likely to be active.
Scientists have known for some years that people who are depressed are at increased risk of heart attack and other cardiac events, however the reason why this should be has remained unclear. However, according to results of a study by Mary A Wooley and colleagues, the increased risk is due to behavioral factors.
The researchers analyzed data obtained from 1,017 people with heart disease, 199 of which had symptoms of depression. Results showed that 10% of depressed participants had a cardiac event (e.g. heart attack, heart failure, stroke, transient ischemic attack) during the study period, compared to just 6.7% of non-depressed participants, meaning that depressed participants were 50% more likely to have a cardiac event. However, results also showed that depressed participants were more likely to smoke, were less likely to take their medications as prescribed, and were less physically active. After the researchers factored these behaviors into their calculations the risk of a cardiac event in depressed participants was similar to that in non-depressed participants.
February is American Heart Month. In recognition of American Heart Month you can access Heart Health Made Easy at a 25% savings. Learn more about this take action guide to lower cholesterol and blood pressure at http://www.hearthealthmadeeasy.com.
All the best,
Lisa Nelson RD
Be Heart Healthy and Lose Weight
Would you like to ask Dr. Cynthia Shelby-Lane, heart health expert, a question?
Dr. Cynthia Shelby-Lane, MD
Well, now’s your chance! I will be interviewing Dr. Cynthia Shelby-Lane later this month. I want to ask the questions you want answers to. Submit your questions by commenting on this post below.
Here’s a little background information on Dr. Shelby-Lane. She’s known as the “agelessdoctor” with a private practice located in Detroit, Michigan – Elan Anti-Aging & Longevity Center of Michigan. After 23 years as an emergency room physician, her experience with life and death crises made her realize the limitations of traditional medicine. She became a board certified anti-aging specialist with a holistic approach to medicine, integrating traditional and complimentary strategies to treat and prevent disease. Dr. Shelby-Lane has recently expanded her practice to the internet and answers questions for patients around the world, providing alternative solutions and second opinions.
Dr. Shelby-Lane’s knowledge is extensive and has led to positions with numerous state and national medical boards, including two terms as President of the American Association of Women Emergency Physicians. Her areas of expertise include cardiovascular disease prevention, bio-identical hormone replacement therapy, detoxification, adrenal and thyroid disorders, weight management, memory and brain health, autoimmune disorders and fibromyalgia.
In a unique twist, Dr. Shelby-Lane not only graduated from the University of Michigan Medical School, but also the Second City Comedy School in Chicago. She’s a firm believer that laughter is good medicine and I have to agree. She’s produced her own comedy show titled “Laugh Attack: Stopping the # 1 Killer – Heart Disease” and delivers a powerful lecture called “Heart Sense & Humor”. You can join her live via satellite radio on February 4th as she discusses heart disease and her upcoming book release.
The list of Dr. Shelby-Lane’s accomplishments is endless (including being a guest on Oprah – more than once!). The above is just a quick synopsis of the ones I thought you’d find most interesting related to heart disease.
Make the most of Dr. Shelby-Lane’s generous offer to carve time out of her busy schedule to answer your questions.
Comment on this post to submit your questions.
This interview will be posted in February as a special feature to recognize “American Heart Month”. So, watch for the answers to your questions next month! Until then, I’d love to have you join the hundreds of people reading The Heart of Health ezine where I provide free heart health and weight loss tips. Subscribers also receive the free report “Stop Wasting Money – Take Control of Your Health” or the free e-course “How to Lower Cholesterol in 8 Simple Steps”.
